內質網膜蛋白復合物亞單位6 (EMC6)是一種新型的胃癌抑癌因子

2017年8月，北京大學基礎醫學院細胞生物學與免疫學系；北京中醫藥大學中日友好醫院學院；北京望京醫院腫瘤科；中國中醫科學院(Departments of Cell Biology and Immunology, School of Basic Medical Science, Peking University, Beijing 100191；College of China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing 100029；Department of Oncology, Wangjing Hospital,China Academy of Chinese Medical Sciences, Beijing 100102, China) Yun Bai老師研究團隊在《BMB Reports》上發表論文：

“ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer”

“內質網膜蛋白復合物亞單位6 (EMC6)是一種新型的胃癌抑癌因子”

Abstract：

The endoplasmic reticulum (ER) membrane protein complex subunit 6 (EMC6) is a novel human autophagy-related molecule. Here, using tissue microarray and immunohistochemistry, we report that EMC6 protein is lost or reduced in glandular cells of patients with gastric adenocarcinoma, compared to normal stomach mucosa. Overexpression of EMC6 in gastric cancer cells inhibited cell growth, migration, invasion, and induced apoptosis and cell cycle arrest at S-phase. Further investigation suggested that EMC6 overexpression in BGC823 human adenocarcinoma gastric cancer cells reduced tumorigenicity in a xenograft model, demonstrating that EMC6 has the characteristics of a tumor suppressor. This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored.

摘要：

內質網(ER)膜蛋白復合物亞單位6 (EMC6)是一種新的人類自噬相關分子。在這里，我們使用組織芯片和免疫組織化學技術，報告了與正常胃粘膜相比，胃腺癌患者的腺體細胞中EMC6蛋白丟失或減少。胃癌細胞中過表達EMC6抑制細胞生長、遷移、侵襲，誘導細胞凋亡和細胞周期阻滯于s期。進一步研究表明，在異種移植模型中，EMC6在BGC823人腺癌胃癌細胞中過表達可降低其致瘤性，表明EMC6具有腫瘤抑制因子的特性。這是**發現EMC6誘導胃癌細胞死亡的研究。EMC6作為腫瘤抑制因子的分子機制有待進一步探索。

該論文中，BGC823和SGC7901細胞體外培養是使用Ausbian特級胎牛血清完成的。欲了解或購買Ausbian特級胎牛血清可以聯系北京締一生物400-166-8600.